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Nature Biotechnology锛氬寲瀛︿笌鍒嗗瓙宸ョ▼瀛﹂櫌璐炬鑺宠棰樼粍涓庡悎浣滆�呭悎浣滄姤閬撲竴绉嶈〃瑙傞仐浼犵紪杈戣偛绉嶆柊鎶�鏈紝鍔╁姏绮澧炰骇锛屾帹鍔ㄥ啘涓氭妧鏈潻鍛?/h1>
浣滆�咃細
鏉ユ簮锛?nbsp;
鍙戝竷鏃ユ湡:2021-07-22
鍖椾含澶у鍖栧涓庡垎瀛愬伐绋嬪闄?/span>璐炬鑺宠棰樼粍鑷村姏浜庣爺绌?/span>RNA鐢插熀鍖?/span>淇グN6-鐢插熀鑵哄槍鍛わ紙m6A锛夎皟鎺?/span>妞嶇墿鐢熼暱鍙戣偛鍙婂埡婵�鍝嶅簲鐨勫垎瀛愭満鍒讹紝缁樺埗浜嗘鐗╂嫙鍗?/span>鑺?/span>鍜岀帀绫崇殑m6A鍏ㄨ浆褰曞浘璋憋紙Nature Communications 2014锛?/span>Plant Physiology 2020锛夛紝閴村畾鍜岃В鏋愪簡妞嶇墿鎷熷崡鑺?/span>涓?/span>m6A鍘讳慨楗伴叾ALKBH10B鍜?/span>m6A缁撳悎铔嬬櫧ECT2銆?/span>CPSF30-L鐨勭敓鐗╁姛鑳斤紙Plant Cell 2017, 2018; Molecular Plant 2021锛?/span>Nature Communications 2021锛夛紝鎺ㄥ姩浜嗘鐗?/span>RNA琛ㄨ閬椾紶瀛?/span>鐨勭爺绌躲�?/span>
2021骞?鏈?/span>22鏃?/span>锛岃淳妗傝姵璇鹃缁?/span>涓?/span>缇庡浗鑺濆姞鍝ュぇ瀛?/span>浣曞窛鏁欐巿璇鹃缁勩�?/span>璐靛窞澶у瀹嬪疂瀹夐櫌澹棰樼粍鍚堜綔锛?/span>鍏卞悓鍦ㄣ�?/span>Nature Biotechnology銆嬩笂鍙戣〃浜嗛涓?/span>鈥淩NA demethylation increases the yield and biomass of rice and potato plants in field trials鈥?/span>鐨勭爺绌惰鏂囥�?/span>璇ョ爺绌跺彂鐜伴�氳繃璋冭妭RNA琛ㄨ閬椾紶淇グm6A鍚噺鍙績杩涙鐗╃敓闀匡紝鎻愰珮浣滅墿浜ч噺鍜?/span>鐢熺墿閲?/span>锛?/span>浣滀负棣栦釜绮澧炰骇鐨?/span>琛ㄨ閬椾紶鑲茬鏂版妧鏈紝鏈潵鏈夋湜鎺ㄨ繘鎴戝浗鍐滀笟鎶�鏈彂灞曘�?/span>
璇ョ爺绌跺湪鍗曞瓙鍙舵鐗╂按绋诲拰鍙屽瓙鍙舵鐗╁湡璞嗕腑寮曞叆FTO锛堝摵涔冲姩鐗╀綋鍐呯殑RNA鍘荤敳鍩哄寲閰讹級瀵规鐗㏑AN琛ㄨ閬椾紶淇グm6A杩涜鍘荤敳鍩哄寲銆傜敯闂磋瘯楠岀粨鏋滆〃鏄庤繃琛ㄨ揪FTO鐨?/span>姘寸ɑ鍜屽湡璞嗙殑浜ч噺鍜岀敓鐗╅噺閮芥樉钁楀鍔犱簡绾?/span>50%銆傝繘涓�姝ョ爺绌跺彂鐜帮紝杩囪〃杈?/span>FTO鍙樉钁椾績杩涙按绋诲垎铇栧舰鎴愬拰鏍圭郴鐢熼暱锛屽寮哄厜鍚堜綔鐢?/span>鏁堢巼鍜屾姉鏃辫兘鍔?/span>銆?/span>FTO鍙壒寮傛�у寮烘牴椤剁鍒嗙敓缁勭粐缁嗚優鐨勫娈栵紝澧炲姞鏍归暱鍜屾牴鐨勬暟鐩紝浠庤�屼績杩涙牴绯荤敓闀裤�傛繁鍏ョ爺绌跺叾鍒嗗瓙鏈虹悊鍙戠幇FTO浠?/span>瀵肩殑m6A鍘荤敳鍩哄寲鍙互淇冭繘鏌撹壊璐ㄧ殑寮�鏀撅紝婵�娲昏浆褰曪紝灏ゅ叾鏄〃鍨嬬浉鍏冲熀鍥犵殑杞綍銆?/span>
璇ョ爺绌跺紑鍙戜簡涓�绉?/span>鍏?/span>鏂扮殑銆佸叿鏈夋櫘閫傛�х殑琛ㄨ閬椾紶缂栬緫鑲茬鎶�鏈?/span>锛?/span>鍙?/span>鐢ㄤ簬鍩硅偛楂樹骇楂樼敓鐗╅噺鐨勪紭鑹搧绉嶏紝瀹炵幇绮澧炰骇銆?/span>姝ゅ鏀归�?/span>鍚庣殑妞嶇墿鏍圭郴鍙戣揪鏈夋湜鏇村姞閫傚簲鎶楁棻銆佹姉閫嗙瓑鐜锛屾湭鏉?/span>璇ユ妧鏈?/span>鏈夋湜搴旂敤浜?/span>妫灄鑽夊師鐢熸�?/span>淇闂銆?/span>
FTO瀵规按绋诲搧绉嶆棩鏈櫞锛?/span>Nipp锛夌殑鏀归�?/span>
FTO瀵?/span>椹搩钖?/span>鍝佺閯傝柉3鍙?/span>锛?/span>EM3锛夌殑鏀归�?/span>
鍖椾含澶у鍖栧涓庡垎瀛愬伐绋嬪闄㈣淳妗傝姵缁勫崥澹悗鍠荤惣锛堜綔鐗?/span>RNA淇グ鐮旂┒锛夛紝鑺濆姞鍝ュぇ瀛?/span>浣曞窛缁勫崥澹?/span>鍚庡垬椤猴紙鐢熺墿淇℃伅瀛﹀垎鏋愶級涓鸿璁烘枃鐨勫叡鍚岀涓�浣滆�?/span>銆?/span>鍖椾含澶у鍖栧涓庡垎瀛愬伐绋嬪闄㈣淳妗傝姵鐮旂┒鍛橈紝鑺濆姞鍝ュぇ瀛︿綍宸濇暀鎺?/span>鍜?/span>璐靛窞澶у瀹嬪疂瀹夐櫌澹负璇ヨ鏂囩殑鍏卞悓閫氳浣滆�?/span>銆?/span>璇ョ爺绌跺緱鍒颁簡鍥藉鑷劧绉戝鍩洪噾銆?/span>鍥藉閲嶇偣鍩虹鐮旂┒鍙戝睍璁″垝椤圭洰銆?/span>鍖椾含甯傝嚜鐒剁瀛﹀熀閲?/span>銆?/span>鍖椾含鍏夊厓绔嬫柟鐢熺墿鎶�鏈湁闄愬叕鍙?/span>鍜?/span>閽熷瓙閫告暀鑲插熀閲?/span>鍜屽寳浜垎瀛愮瀛﹀浗瀹剁爺绌朵腑蹇?/span>鐨勮祫鍔?/span>銆?/span>
鍘熸枃閾炬帴锛?/span>//www.nature.com/articles/s41587-021-00982-9