伊人直播

Abstract

Hypervalent iodine(III) compounds are versatile, highly electrophilic reagents that enable functional group transfer (arylation, amination, fluorination, fluoroalkylation, etc.) under metal-catalysed or metal-free conditions. Alkylation, however, is a challenging transfor-mation for these compounds, as they undergo rapid alpha- and beta-elimination.

Our group aims to understand these competing reactions and design stable iodine(III) reagents for (fluoro)alkylation. We have recently reported the hypervalent-iodine mediated 1,1-difluoroethyla-tion of heteroatom nucleophiles, providing access to a variety of pharmaceutically relevant molecules bearing this motif, that can act as a lipophilic hydrogen-bond donor.

Biography

Miriam O’Duill received her D.Phil. in Organic Chemistry from the University of Oxford in 2016, where she carried out research on late-stage fluorination with Prof. Véronique Gouverneur. She spent two years as a DAAD postdoctoral fellow at the Scripps Research Institute, La Jolla, investigating selective catalytic functionalization of alkenes and alkynes with Prof. Keary M. Engle. In 2018, Miriam began her independent career at the University of Galway in Ireland, before accepting a position as Assistant Professor at the University of Nottingham in 2020. Her research interests span transition metal catalysis, isotopic labelling for medical imaging, and the development of sustainable, metal-free reaction methodology using hypervalent iodine reagents.